New Type of BACE1 siRNA Delivery to Cells
نویسندگان
چکیده
منابع مشابه
New Type of BACE1 siRNA Delivery to Cells
BACKGROUND Small interfering RNA (siRNA) gene therapy is a new molecular approach in the search for an efficient therapy for Alzheimer disease (AD), based on the principle of RNA interference. Reducing BACE activity can have great therapeutic potential for the treatment of AD. In this study, receptor-mediated delivery was used to deliver opioid peptide-conjugated BACE 1 to INR-32 human neurobla...
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The fluorescent quantum dots (QDs) delivered small interfering RNAs (siRNAs) targeting β-secretase (BACE1) to achieve high transfection efficiency of siRNAs and reduction of β-amyloid (Aβ) in nerve cells. The CdSe/ZnS QDs with the conjugation of amino-polyethylene glycol (PEG) were synthesized. Negatively charged siRNAs were electrostatically adsorbed to the surface of QDs to develop QD-PEG/siR...
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ژورنال
عنوان ژورنال: Medical Science Monitor
سال: 2014
ISSN: 1643-3750
DOI: 10.12659/msm.891219